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| 12.03.2022 | FC Juárez | - | Pumas UNAM | 2:3 (1:1) | ||
| 15:00 | Atlético San Luis | - | Deportivo Guadalajara | 0:1 (0:0) | ||
| 16:00 | UANL Tigres | - | Club León | 2:1 (0:1) | ||
| 16:00 | Atlas Guadalajara | - | Santos Laguna | 2:3 (0:2) | ||
| 16:00 | Deportivo Toluca | - | Puebla FC | 3:4 (1:1) | ||
| 18:00 | CF Pachuca | - | Cruz Azul | 2:2 (1:2) | ||
| 19:30 | Mazatlán FC | - | CF Monterrey | 2:3 (0:2) | ||
| 23:00 | CF América | - | Gallos Blancos | 1:1 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Cruz Azul | 9 | 6 | 1 | 2 | 21:12 | 9 | 19 |
| 2 |
|
Pumas UNAM | 9 | 5 | 1 | 3 | 14:8 | 6 | 16 |
| 3 |
|
CF América | 9 | 5 | 1 | 3 | 14:11 | 3 | 16 |
| 4 |
|
Puebla FC | 9 | 4 | 2 | 3 | 17:10 | 7 | 14 |
| 5 |
|
Deportivo Toluca | 9 | 4 | 2 | 3 | 22:16 | 6 | 14 |
| 6 |
|
CF Pachuca | 9 | 2 | 4 | 3 | 18:21 | -3 | 10 |
| 7 |
|
Club Necaxa | 8 | 2 | 4 | 2 | 11:15 | -4 | 10 |
| 8 |
|
FC Juárez | 9 | 2 | 1 | 6 | 11:22 | -11 | 7 |
| 9 |
|
Gallos Blancos | 9 | 1 | 2 | 6 | 6:19 | -13 | 5 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 9 | 6 | 2 | 1 | 21:9 | 12 | 20 |
| 2 |
|
Atlas Guadalajara | 9 | 5 | 2 | 2 | 21:13 | 8 | 17 |
| 3 |
|
UANL Tigres | 9 | 4 | 3 | 2 | 12:11 | 1 | 15 |
| 4 |
|
Santos Laguna | 9 | 4 | 2 | 3 | 13:10 | 3 | 14 |
| 5 |
|
Club León | 9 | 3 | 2 | 4 | 11:13 | -2 | 11 |
| 6 |
|
CF Monterrey | 9 | 2 | 4 | 3 | 14:12 | 2 | 10 |
| 7 |
|
Club Tijuana | 8 | 3 | 1 | 4 | 7:12 | -5 | 10 |
| 8 |
|
Mazatlán FC | 9 | 2 | 2 | 5 | 12:22 | -10 | 8 |
| 9 |
|
Atlético San Luis | 9 | 1 | 2 | 6 | 7:16 | -9 | 5 |
| Playoff | |
| Playoff |
