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| 12.09.2021 | 16:00 | FK AP Brera Strumica | - | Makedonija GP | 4:1 (2:1) | |
| 16:00 | FK Borec | - | FK Pelister | 2:1 (1:1) | ||
| 16:00 | FK Rabotnički | - | FK Bregalnica Štip | 2:0 (1:0) | ||
| 16:00 | FC Struga | - | FK Skopje | 1:0 (0:0) | ||
| 16:00 | GFK Tikvesh | - | FK Renova | 0:2 (0:1) | ||
| 14.09.2021 | 15:00 | KF Shkëndija 79 | - | KF Shkupi | 0:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FK AP Brera Strumica | 6 | 4 | 1 | 1 | 13:6 | 7 | 13 |
| 2 |
|
FC Struga | 6 | 3 | 3 | 0 | 8:4 | 4 | 12 |
| 3 |
|
KF Shkupi | 6 | 3 | 2 | 1 | 10:5 | 5 | 11 |
| 4 |
|
FK Renova | 6 | 3 | 2 | 1 | 9:5 | 4 | 11 |
| 5 |
|
FK Rabotnički | 6 | 3 | 2 | 1 | 6:4 | 2 | 11 |
| 6 |
|
Makedonija GP | 6 | 3 | 0 | 3 | 10:13 | -3 | 9 |
| 7 |
|
KF Shkëndija 79 | 6 | 1 | 4 | 1 | 10:7 | 3 | 7 |
| 8 |
|
FK Bregalnica Štip | 6 | 1 | 4 | 1 | 7:8 | -1 | 7 |
| 9 |
|
FK Borec | 6 | 2 | 1 | 3 | 7:9 | -2 | 7 |
| 10 |
|
FK Skopje | 6 | 1 | 2 | 3 | 4:11 | -7 | 5 |
| 11 |
|
GFK Tikvesh | 6 | 0 | 2 | 4 | 3:9 | -6 | 2 |
| 12 |
|
FK Pelister | 6 | 0 | 1 | 5 | 3:9 | -6 | 1 |
| CL Ronda previa | |
| ECL Ronda previa | |
| Permanencia | |
| Descenso |
