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| 18.08.2010 | 17:00 | FK Osogovo | - | Prevalec | 6:0 | |
| 17:00 | FK Bregalnica Štip | - | FK Ohrid Lote | 3:1 | ||
| 17:00 | Lokomotiva Skopje | - | FK Belasica | 1:0 | ||
| 17:00 | FK Miravci | - | FK Rabotnički | 1:0 | ||
| 17:00 | FK Ohrid | - | Sileks Kratovo | 0:1 | ||
| 17:00 | KF Gostivari | - | Milano Kumanovo | 3:0 | ||
| 17:00 | FK Novaci 2005 | - | Vardar Skopje | 2:3 | ||
| 17:00 | FK Vlaznimi | - | KF Shkëndija 79 | 5:4 pn. | ||
| 17:00 | FK Bair Krkardaš | - | FK Pelister | 1:3 | ||
| 17:00 | GFK Tikvesh | - | FK Drita | 2:1 | ||
| 17:00 | Prespa Resen | - | Metalurg Skopje | 0:7 | ||
| 17:00 | FK Gorno Lisiče | - | Napredok Kičevo | 1:4 pn. | ||
| 17:00 | FK Karbinci | - | FK Turnovo | 0:5 | ||
| 17:00 | Kamenica Sasa | - | FK Teteks | 1:2 | ||
| 17:00 | Cementarnica Skopje | - | FK Renova | 0:1 |
