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| I | FK Renova | - | KF Gostivari | 0:1 (0:0) | ||
| V | KF Gostivari | - | FK Renova | 1:5 (0:3) | ||
| I: 13.09.2011 15:30 | V: 28.09.2011 14:30 | Campeones: FK Renova | ||||
| I | Sileks Kratovo | - | FK Teteks | 2:2 (1:1) | ||
| V | FK Teteks | - | Sileks Kratovo | 0:0 (0:0) | ||
| I: 14.09.2011 15:30 | V: 28.09.2011 14:30 | Campeones: FK Teteks | ||||
| I | 11 Oktomvri | - | FK Skopje | 4:0 (3:0) | ||
| V | FK Skopje | - | 11 Oktomvri | 2:0 (0:0) | ||
| I: 14.09.2011 15:30 | V: 29.09.2011 14:30 | Campeones: 11 Oktomvri | ||||
| I | KF Shkëndija 79 | - | FK Bregalnica Štip | 2:0 (0:0) | ||
| V | FK Bregalnica Štip | - | KF Shkëndija 79 | 3:0 (1:0, 2:0) pn. | ||
| I: 14.09.2011 15:30 | V: 28.09.2011 14:30 | Campeones: FK Bregalnica Štip | ||||
| I | FK Turnovo | - | FK Pelister | 1:0 | ||
| V | FK Pelister | - | FK Turnovo | 1:1 (0:0) | ||
| I: 14.09.2011 15:30 | V: 28.09.2011 14:30 | Campeones: FK Turnovo | ||||
| I | Napredok Kičevo | - | FK Miravci | 3:1 (2:0) | ||
| V | FK Miravci | - | Napredok Kičevo | 2:3 | ||
| I: 14.09.2011 15:30 | V: 28.09.2011 14:30 | Campeones: Napredok Kičevo | ||||
| I | FK Rabotnički | - | Metalurg Skopje | 0:0 | ||
| V | Metalurg Skopje | - | FK Rabotnički | 3:5 (0:0, 0:0) pn. | ||
| I: 14.09.2011 15:30 | V: 28.09.2011 14:30 | Campeones: FK Rabotnički | ||||
| I | Vardar Skopje | - | GFK Tikvesh | 6:1 (4:1) | ||
| V | GFK Tikvesh | - | Vardar Skopje | 0:1 (0:0) | ||
| I: 15.09.2011 18:30 | V: 28.09.2011 14:30 | Campeones: Vardar Skopje | ||||
