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| 05.10.2022 | 14:00 | FC Struga | - | FK Rabotnički | -:- | |
| 14:00 | FK Bregalnica Štip | - | FK Pelister | -:- | ||
| 14:00 | Vardar Skopje | - | FK Fortuna | -:- | ||
| 14:00 | Akademija Pandev | - | FK Ljuboten | -:- | ||
| 14:00 | FK Pobeda Junior | - | Makedonija GP | -:- | ||
| 14:00 | KF Shkupi | - | FK Voska Sport | -:- | ||
| 14:00 | KF Shkëndija 79 | - | FK Skopje | -:- | ||
| 14:00 | GFK Tikveš | - | Sileks Kratovo | -:- |
