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| 07.05.2022 | 14:30 | VVOG Harderwijk | - | FC Lisse | 0:2 (0:2) | |
| 14:30 | HSV Hoek | - | Sportlust '46 | 0:4 (0:3) | ||
| 14:30 | Harkemase Boys | - | Excelsior '31 | 2:0 (1:0) | ||
| 14:30 | ACV Assen | - | DVS'33 | 1:3 (0:1) | ||
| 14:30 | ODIN '59 | - | AFC Ajax Zaterdag | 3:2 (2:2) | ||
| 14:30 | SteDoCo | - | BVV Barendrecht | 2:2 (0:1) | ||
| 15:00 | Sparta Nijkerk | - | VV GOES | 6:2 (3:1) | ||
| 15:00 | VV DOVO Veenendaal | - | Ter Leede | 3:1 (0:1) | ||
| 18:00 | VV Sint Bavo | - | VV Staphorst | 2:1 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Lisse | 29 | 18 | 5 | 6 | 58:34 | 24 | 59 |
| 2 |
|
Sportlust '46 | 29 | 16 | 6 | 7 | 56:33 | 23 | 54 |
| 3 |
|
Sparta Nijkerk | 29 | 15 | 7 | 7 | 53:32 | 21 | 52 |
| 4 |
|
Excelsior '31 | 29 | 13 | 7 | 9 | 48:39 | 9 | 46 |
| 5 |
|
HSV Hoek | 29 | 13 | 7 | 9 | 44:41 | 3 | 46 |
| 6 |
|
DVS'33 | 29 | 14 | 3 | 12 | 49:36 | 13 | 45 |
| 7 |
|
BVV Barendrecht | 29 | 11 | 11 | 7 | 62:46 | 16 | 44 |
| 8 |
|
VV Staphorst | 29 | 12 | 6 | 11 | 44:42 | 2 | 42 |
| 9 |
|
ACV Assen | 29 | 11 | 8 | 10 | 39:34 | 5 | 41 |
| 10 |
|
SteDoCo | 29 | 11 | 6 | 12 | 46:45 | 1 | 39 |
| 11 |
|
Harkemase Boys | 29 | 9 | 10 | 10 | 53:49 | 4 | 37 |
| 12 |
|
Ter Leede | 29 | 11 | 4 | 14 | 37:53 | -16 | 37 |
| 13 |
|
ODIN '59 | 29 | 9 | 7 | 13 | 44:57 | -13 | 34 |
| 14 |
|
VV Sint Bavo | 29 | 9 | 6 | 14 | 44:55 | -11 | 33 |
| 15 |
|
VVOG Harderwijk | 29 | 8 | 7 | 14 | 50:70 | -20 | 31 |
| 16 |
|
VV DOVO Veenendaal | 29 | 7 | 8 | 14 | 33:50 | -17 | 29 |
| 17 |
|
AFC Ajax Zaterdag | 29 | 8 | 5 | 16 | 31:49 | -18 | 29 |
| 18 |
|
VV GOES | 29 | 5 | 9 | 15 | 41:67 | -26 | 24 |
| Ascenso | |
| Permanencia | |
| Descenso |
