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| 21.05.2022 | 14:30 | HSV Hoek | - | Excelsior '31 | 2:1 (1:1) | |
| 14:30 | ACV Assen | - | VVOG Harderwijk | 3:1 (2:0) | ||
| 14:30 | ODIN '59 | - | VV Sint Bavo | 2:2 (1:1) | ||
| 14:30 | DVS'33 | - | AFC Ajax Zaterdag | 1:0 (0:0) | ||
| 14:30 | SteDoCo | - | Sportlust '46 | 0:0 (0:0) | ||
| 14:30 | Ter Leede | - | BVV Barendrecht | 3:2 (2:1) | ||
| 15:00 | FC Lisse | - | VV GOES | 4:0 (2:0) | ||
| 15:00 | Sparta Nijkerk | - | Harkemase Boys | 4:1 (2:0) | ||
| 15:00 | VV DOVO Veenendaal | - | VV Staphorst | 2:1 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Lisse | 31 | 20 | 5 | 6 | 64:34 | 30 | 65 |
| 2 |
|
Sparta Nijkerk | 31 | 17 | 7 | 7 | 61:33 | 28 | 58 |
| 3 |
|
Sportlust '46 | 31 | 16 | 7 | 8 | 56:35 | 21 | 55 |
| 4 |
|
DVS'33 | 31 | 15 | 4 | 12 | 51:37 | 14 | 49 |
| 5 |
|
HSV Hoek | 31 | 14 | 7 | 10 | 46:45 | 1 | 49 |
| 6 |
|
BVV Barendrecht | 31 | 12 | 11 | 8 | 67:50 | 17 | 47 |
| 7 |
|
ACV Assen | 31 | 13 | 8 | 10 | 45:36 | 9 | 47 |
| 8 |
|
Excelsior '31 | 31 | 13 | 7 | 11 | 49:45 | 4 | 46 |
| 9 |
|
VV Staphorst | 31 | 12 | 6 | 13 | 46:47 | -1 | 42 |
| 10 |
|
Ter Leede | 31 | 12 | 5 | 14 | 41:56 | -15 | 41 |
| 11 |
|
Harkemase Boys | 31 | 10 | 10 | 11 | 57:55 | 2 | 40 |
| 12 |
|
SteDoCo | 31 | 11 | 7 | 13 | 46:47 | -1 | 40 |
| 13 |
|
VV Sint Bavo | 31 | 10 | 7 | 14 | 48:57 | -9 | 37 |
| 14 |
|
ODIN '59 | 31 | 9 | 8 | 14 | 46:60 | -14 | 35 |
| 15 |
|
AFC Ajax Zaterdag | 31 | 9 | 5 | 17 | 34:50 | -16 | 32 |
| 16 |
|
VV DOVO Veenendaal | 31 | 8 | 8 | 15 | 36:54 | -18 | 32 |
| 17 |
|
VVOG Harderwijk | 31 | 8 | 7 | 16 | 53:76 | -23 | 31 |
| 18 |
|
VV GOES | 31 | 6 | 9 | 16 | 42:71 | -29 | 27 |
| Ascenso | |
| Permanencia | |
| Descenso |
