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| I | AFC Ajax | - | FC Groningen | 3:0 (0:0) | ||
| V | FC Groningen | - | AFC Ajax | 1:1 (0:0) | ||
| I: 25.02.1981 | V: 18.03.1981 | Campeones: AFC Ajax | ||||
| I | Go Ahead Eagles | - | PEC Zwolle | 1:1 (0:0) | ||
| V | PEC Zwolle | - | Go Ahead Eagles | 1:2 (0:0, 1:1) pró. | ||
| I: 25.02.1981 | V: 21.03.1981 | Campeones: Go Ahead Eagles | ||||
| I | SBV Haarlem | - | AZ '67 Alkmaar | 1:1 (1:1) | ||
| V | AZ '67 Alkmaar | - | SBV Haarlem | 3:1 (1:0) | ||
| I: 25.02.1981 | V: 01.04.1981 | Campeones: AZ '67 Alkmaar | ||||
| I | Willem II | - | PSV | 0:1 (0:1) | ||
| V | PSV | - | Willem II | 2:0 (0:0) | ||
| I: 25.02.1981 | V: 11.03.1981 | Campeones: PSV | ||||
