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| 13.08.2022 | 17:00 | JOS Watergraafsmeer | - | HSV Hoek | 1:3 (0:2) | |
| 17:00 | USV Hercules | - | Ter Leede | 5:1 (2:1) | ||
| 17:00 | RKSV Groene Ster | - | BVV Barendrecht | 2:0 (0:0) | ||
| 17:00 | VV OJC Rosmalen | - | Sportlust '46 | 1:2 (0:1) | ||
| 17:00 | VV Staphorst | - | SV TOGB | 3:0 (1:0) | ||
| 19:00 | ADO '20 | - | VVOG Harderwijk | 4:3 (1:1, 3:3, 4:3) pró. |
