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| 11.12.2010 | 14:30 | Larne FC | - | Bangor FC | 2:1 | |
| 14:30 | Institute FC Drumahoe | - | Newington Youth Club | 5:4 pn. | ||
| 14:30 | Banbridge Town | - | Shankill United | 0:1 | ||
| 14:30 | Armagh City FC | - | Crumlin United | 2:3 | ||
| 14:30 | Tobermore United | - | Loughgall FC | 3:5 | ||
| 14:30 | Dundela FC | - | Chimney Corner FC | 5:0 | ||
| 14:30 | Lurgan Celtic | - | Dunmurry Recreation | 4:5 pn. | ||
| 14:30 | Dergview FC | - | Ballinamallard United FC | 2:3 | ||
| 14:30 | Annagh United | - | Killymoon Rangers | 2:1 | ||
| 14:30 | Queen's University Belfast | - | PSNI FC | 3:2 | ||
| 14:30 | Sport & Leisure Swifts | - | Dungiven Celtic | 5:3 | ||
| 14:30 | Warrenpoint Town | - | Comber Recreation | 3:2 | ||
| 14:30 | Moyola Park FC | - | Carrick Rangers | 1:6 | ||
| 14:30 | Albert Foundry FC | - | Rosario Youth Club | 3:1 | ||
| 14:30 | Knockbreda FC | - | Ballymoney United | 0:2 | ||
| 14:30 | Portstewart FC | - | Kilmore Recreation FC | 0:2 | ||
| 16:00 | Ballyclare Comrades | - | H&W Welders | 2:4 | ||
| 03.01.2011 | 14:30 | Glebe Rangers | - | Nortel FC | 1:2 | |
| 15.01.2011 | 14:30 | Coagh United | - | Ards FC | 2:5 | |
| 16:00 | Limavady United | - | Wakehurst FC | 2:0 |
