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| 04.02.2022 | 20:45 | Larne FC | - | Linfield FC | 2:0 | |
| 20:45 | Newry City FC | - | Dundela FC | 1:0 | ||
| 05.02.2022 | 14:30 | Queen's University Belfast | - | Glentoran FC | 0:4 | |
| 16:00 | Ballinamallard United FC | - | Crusaders FC | 0:1 | ||
| 16:00 | Carrick Rangers | - | Cliftonville FC | 0:1 | ||
| 16:00 | Coleraine FC | - | Portadown FC | 2:0 | ||
| 16:00 | Dungannon Swifts | - | Annagh United | 4:1 | ||
| 15.02.2022 | 20:45 | Ballymena United | - | Portstewart FC | 3:0 |
