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| 14.09.2021 | 20:45 | Crusaders FC | - | Moyola Park FC | 5:0 | |
| 20:45 | Institute FC Drumahoe | - | PSNI FC | 0:3 | ||
| 20:45 | Portadown FC | - | Newington Youth Club | 2:0 | ||
| 20:45 | Dungannon Swifts | - | Armagh City FC | 3:0 | ||
| 20:45 | Ballyclare Comrades | - | Linfield FC | 0:4 | ||
| 20:45 | Glenavon FC | - | Portstewart FC | 5:1 | ||
| 20:45 | Annagh United | - | Ballymena United | 2:4 | ||
| 20:45 | Glentoran FC | - | Banbridge Town | 5:0 | ||
| 20:45 | Loughgall FC | - | Lisburn Distillery | 6:2 | ||
| 20:45 | Carrick Rangers | - | Dergview FC | 2:1 pró. | ||
| 20:45 | Newry City FC | - | Warrenpoint Town | 1:2 pró. | ||
| 20:45 | Dundela FC | - | Ballinamallard United FC | 0:4 pró. | ||
| 20:45 | Cliftonville FC | - | H&W Welders | 2:0 | ||
| 21:00 | Larne FC | - | Limavady United | 0:3 | ||
| 21:00 | Bangor FC | - | Coleraine FC | 0:5 | ||
| 15.09.2021 | 21:00 | Ards FC | - | Dollingstown FC | 4:0 |
