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| 04.10.2022 | 20:45 | Annagh United | - | Larne FC | 2:1 | |
| 20:45 | Ballyclare Comrades | - | Newry City FC | 1:2 | ||
| 20:45 | Ballymena United | - | Coleraine FC | 0:1 | ||
| 20:45 | Cliftonville FC | - | Carrick Rangers | 6:0 | ||
| 20:45 | Dundela FC | - | Linfield FC | 0:1 | ||
| 20:45 | Dungannon Swifts | - | Portadown FC | 2:1 pró. | ||
| 20:45 | Glenavon FC | - | Loughgall FC | 1:2 | ||
| 20:45 | Glentoran FC | - | Warrenpoint Town | 6:0 |
