| 2. Jornada | 03.04.2021 | Deportes Melipilla | - | Ñublense | 1:1 | ||||
| 3. Jornada | 10.04.2021 | Unión Española | - | Deportes Melipilla | 0:2 | ||||
| 4. Jornada | 16.04.2021 | Deportes Melipilla | - | Palestino | 0:1 | ||||
| 5. Jornada | 27.04.2021 | Audax Italiano | - | Deportes Melipilla | 1:0 | ||||
| 7. Jornada | 09.05.2021 | Santiago Wanderers | - | Deportes Melipilla | 0:3 |  |
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| 12. Jornada | 24.07.2021 | Deportes Melipilla | - | Unión La Calera | 3:3 | ||||
| 17. Jornada | 22.08.2021 | Deportes Melipilla | - | Huachipato | 1:2 | ||||
| 20. Jornada | 07.09.2021 | Deportes Melipilla | - | Unión Española | 0:3 | ||||
| 21. Jornada | 15.09.2021 | Palestino | - | Deportes Melipilla | 3:1 |
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Chile