| 1. Jornada | 25.07.2021 | Pumas UNAM [Sub 20] | - | Atlas Guadalajara [Sub 20] | 1:0 | ||||
| 2. Jornada | 31.07.2021 | CF Monterrey [Sub 20] | - | Pumas UNAM [Sub 20] | 3:1 | ||||
| 3. Jornada | 08.08.2021 | Pumas UNAM [Sub 20] | - | Atlético San Luis [Sub 20] | 5:3 | ||||
| 4. Jornada | 14.08.2021 | Pumas UNAM [Sub 20] | - | Gallos Blancos [Sub 20] | 1:4 | ||||
| 5. Jornada | 17.08.2021 | Club Necaxa [Sub 20] | - | Pumas UNAM [Sub 20] | 1:1 | ||||
| 6. Jornada | 22.08.2021 | Pumas UNAM [Sub 20] | - | Puebla FC [Sub 20] | 1:3 | ||||
| 7. Jornada | 29.08.2021 | Deportivo Toluca [Sub 20] | - | Pumas UNAM [Sub 20] | 2:2 | ||||
| 9. Jornada | 18.09.2021 | Mazatlán FC [Sub 20] | - | Pumas UNAM [Sub 20] | 2:1 |
México