| 11. Jornada | 20.02.2021 | FC Sheriff | - | FC Sfîntul Gheorghe | 4:1 |  |
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| 22. Jornada | 24.02.2021 | FC Zimbru | - | FC Sheriff | 0:4 | ||||
| 23. Jornada | 01.03.2021 | FC Milsami | - | FC Sheriff | 0:1 | ||||
| 24. Jornada | 06.03.2021 | FC Sheriff | - | Dinamo-Auto | 7:0 | |
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| 25. Jornada | 13.03.2021 | FC Floreşti | - | FC Sheriff | 0:6 | |
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| 26. Jornada | 19.03.2021 | FC Sheriff | - | CS Petrocub | 0:0 | ||||
| 27. Jornada | 11.04.2021 | Dacia Buiucani | - | FC Sheriff | 0:4 | |
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| 28. Jornada | 16.04.2021 | Speranţa Nisporeni | - | FC Sheriff | 0:10 | |
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| 29. Jornada | 24.04.2021 | FC Sheriff | - | FC Sfîntul Gheorghe | 2:0 | |
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| 30. Jornada | 29.04.2021 | FC Codru Lozova | - | FC Sheriff | 0:6 | ||||
| 31. Jornada | 08.05.2021 | FC Zimbru | - | FC Sheriff | 0:1 |  |
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| 32. Jornada | 12.05.2021 | FC Sheriff | - | FC Milsami | 6:0 | |
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| 33. Jornada | 15.05.2021 | Dinamo-Auto | - | FC Sheriff | 0:7 | |
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| 35. Jornada | 22.05.2021 | CS Petrocub | - | FC Sheriff | 0:1 | ||||
| 36. Jornada | 26.05.2021 | FC Sheriff | - | Dacia Buiucani | 1:1 |
Malí