| 2. Jornada | 20.01.2021 | River Plate | - | CA Cerro | 1:2 | ||||
| 3. Jornada | 01.02.2021 | Defensor Sporting | - | River Plate | 0:2 | ||||
| 4. Jornada | 04.02.2021 | River Plate | - | Danubio | 0:4 | ||||
| 5. Jornada | 08.02.2021 | Nacional | - | River Plate | 3:0 | ||||
| 7. Jornada | 14.02.2021 | Deportivo Maldonado | - | River Plate | 1:2 | ||||
| 8. Jornada | 17.02.2021 | River Plate | - | Rentistas | 1:1 | ||||
| 9. Jornada | 20.02.2021 | River Plate | - | Cerro Largo | 2:0 | ||||
| 10. Jornada | 27.02.2021 | River Plate | - | Montevideo Wanderers | 1:1 | ||||
| 12. Jornada | 14.03.2021 | Liverpool | - | River Plate | 3:2 |
Uruguay