| 2. Jornada | 19.09.2021 | Lamia | - | Olympiacos | 1:2 | ||||
| 4. Jornada | 26.09.2021 | Asteras Tripolis | - | Olympiacos | 0:2 |  |
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| 5. Jornada | 03.10.2021 | Olympiacos | - | Panathinaikos | 0:0 | ||||
| 6. Jornada | 17.10.2021 | PAS Giannina | - | Olympiacos | 1:2 | |
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| 7. Jornada | 24.10.2021 | Olympiacos | - | PAOK Saloniki | 2:1 | |
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| 8. Jornada | 30.10.2021 | Panetolikos | - | Olympiacos | 1:2 | ||||
| 9. Jornada | 07.11.2021 | Olympiacos | - | Ionikos Nikea | 1:0 | |
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| 10. Jornada | 21.11.2021 | AEK Athen | - | Olympiacos | 2:3 | |
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| 11. Jornada | 28.11.2021 | Olympiacos | - | Volos NFC | 2:1 | ||||
| 12. Jornada | 04.12.2021 | OFI Heraklion | - | Olympiacos | 1:3 | ||||
| 13. Jornada | 12.12.2021 | Olympiacos | - | Aris Saloniki | 1:0 | ||||
| 14. Jornada | 15.12.2021 | Atromitos | - | Olympiacos | 0:3 | ||||
| 15. Jornada | 19.12.2021 | Olympiacos | - | Lamia | 1:0 | ||||
| 20. Jornada | 30.01.2022 | PAOK Saloniki | - | Olympiacos | 1:1 | |
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| 21. Jornada | 02.02.2022 | Olympiacos | - | Panetolikos | 3:1 | ||||
| 22. Jornada | 06.02.2022 | Ionikos Nikea | - | Olympiacos | 0:3 | |
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| 23. Jornada | 13.02.2022 | Olympiacos | - | AEK Athen | 1:0 | ||||
| 24. Jornada | 20.02.2022 | Volos NFC | - | Olympiacos | 0:1 | ||||
| 17. Jornada | 02.03.2022 | Olympiacos | - | Asteras Tripolis | 5:1 |
Guinea