| 1. Jornada | 17.01.2021 | Nacional | - | Rentistas | 1:1 |  |
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| 2. Jornada | 20.01.2021 | Cerro Largo | - | Nacional | 0:0 | |
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| 3. Jornada | 31.01.2021 | Nacional | - | Montevideo Wanderers | 2:1 | ||||
| 4. Jornada | 03.02.2021 | Peñarol | - | Nacional | 0:0 | |
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| 5. Jornada | 08.02.2021 | Nacional | - | River Plate | 3:0 | ||||
| 6. Jornada | 11.02.2021 | Montevideo City Torque | - | Nacional | 1:2 | ||||
| 8. Jornada | 18.02.2021 | Progreso | - | Nacional | 0:1 | ||||
| 9. Jornada | 22.02.2021 | Nacional | - | Fénix | 2:2 | |
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| 11. Jornada | 08.03.2021 | Nacional | - | Defensor Sporting | 2:1 | ||||
| 12. Jornada | 13.03.2021 | Danubio | - | Nacional | 2:1 | ||||
| 13. Jornada | 22.03.2021 | Nacional | - | Liverpool | 0:4 | ||||
| 14. Jornada | 25.03.2021 | Nacional | - | Boston River | 1:2 | ||||
| 15. Jornada | 29.03.2021 | Deportivo Maldonado | - | Nacional | 1:2 | |
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