| 1. Jornada | 23.07.2022 | UD Universitario | - | San Francisco FC | 1:0 | ||||
| 3. Jornada | 06.08.2022 | San Francisco FC | - | Atlético Chiriquí | 0:0 |  |
|||
| 4. Jornada | 09.08.2022 | Veraguas United | - | San Francisco FC | 3:1 | ||||
| 5. Jornada | 13.08.2022 | San Francisco FC | - | Herrera FC | 5:0 | ||||
| 6. Jornada | 20.08.2022 | Árabe Unido | - | San Francisco FC | 2:0 | |
|||
| 10. Jornada | 17.09.2022 | Plaza Amador | - | San Francisco FC | 1:2 | ||||
| 12. Jornada | 28.09.2022 | San Francisco FC | - | UD Universitario | 1:1 | ||||
| 15. Jornada | 15.10.2022 | San Francisco FC | - | Veraguas United | 1:1 | ||||
| 16. Jornada | 23.10.2022 | Herrera FC | - | San Francisco FC | 0:2 |
Panamá