| 3. Jornada | 02.10.2021 | Cimarrones de Sonora II | - | Saltillo FC | 2:2 | ||||
| 4. Jornada | 09.10.2021 | Saltillo FC | - | Correcaminos UAT II | 1:0 | ||||
| 5. Jornada | 13.10.2021 | Saltillo FC | - | Tritones Vallarta | 2:0 |  |
|||
| 6. Jornada | 16.10.2021 | Catedráticos Elite | - | Saltillo FC | 1:0 |  |
|||
| 7. Jornada | 23.10.2021 | Saltillo FC | - | Gavilanes de Matamoros | 3:1 | |
|||
| 8. Jornada | 31.10.2021 | Mazorqueros | - | Saltillo FC | 1:2 | ||||
| 9. Jornada | 06.11.2021 | Saltillo FC | - | Tecos Fútbol Club | 3:1 | ||||
| 10. Jornada | 11.11.2021 | Colima FC | - | Saltillo FC | 1:2 | ||||
| 11. Jornada | 13.11.2021 | Saltillo FC | - | Leones Negros II | 3:1 | ||||
| 12. Jornada | 20.11.2021 | Coras de Nayarit | - | Saltillo FC | 0:1 | |
|||
| 13. Jornada | 27.11.2021 | Saltillo FC | - | Mineros de Fresnillo FC | 4:2 |
México