| 5. Jornada | 21.08.2021 | Cruz Azul [Sub 16] | - | Deportivo Toluca [Sub 16] | 1:2 |  |
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| 7. Jornada | 04.09.2021 | Cruz Azul [Sub 16] | - | FC Juárez [Sub 16] | 1:0 | ||||
| 9. Jornada | 18.09.2021 | CF América [Sub 16] | - | Cruz Azul [Sub 16] | 1:2 | ||||
| 10. Jornada | 25.09.2021 | Cruz Azul [Sub 16] | - | CF Pachuca [Sub 16] | 1:2 | ||||
| 11. Jornada | 02.10.2021 | Cruz Azul [Sub 16] | - | Gallos Blancos [Sub 16] | 1:0 | ||||
| 8. Jornada | 20.10.2021 | Puebla FC [Sub 16] | - | Cruz Azul [Sub 16] | 1:2 | ||||
| 14. Jornada | 23.10.2021 | Cruz Azul [Sub 16] | - | CF América [Sub 16] | 2:2 | ||||
| 16. Jornada | 06.11.2021 | Cruz Azul [Sub 16] | - | Puebla FC [Sub 16] | 0:2 | ||||
| 18. Jornada | 20.11.2021 | Club Tijuana [Sub 16] | - | Cruz Azul [Sub 16] | 0:0 |
México