| 1. Jornada | 23.01.2022 | Valledupar FC | - | Real Santander | 1:0 | ||||
| 2. Jornada | 29.01.2022 | Atlético FC | - | Valledupar FC | 0:0 | ||||
| 3. Jornada | 06.02.2022 | Valledupar FC | - | Leones FC | 0:1 | ||||
| 8. Jornada | 11.03.2022 | Boyacá Chicó | - | Valledupar FC | 2:2 | ||||
| 9. Jornada | 20.03.2022 | Valledupar FC | - | Boca Juniors de Cali | 2:1 |  |
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| 11. Jornada | 03.04.2022 | Tigres FC | - | Valledupar FC | 3:2 | ||||
| 12. Jornada | 10.04.2022 | Valledupar FC | - | Fortaleza FC | 1:1 | ||||
| 13. Jornada | 16.04.2022 | Barranquilla FC | - | Valledupar FC | 1:1 |
Colombia