| 16. Jornada | 27.11.2021 | Cercle Brugge | - | KV Mechelen | 3:1 | ||||
| 18. Jornada | 12.12.2021 | Union Saint-Gilloise | - | KV Mechelen | 2:0 |  |
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| 19. Jornada | 15.12.2021 | KV Mechelen | - | Gante | 4:3 | ||||
| 20. Jornada | 18.12.2021 | SV Zulte Waregem | - | KV Mechelen | 3:2 | ||||
| 26. Jornada | 06.02.2022 | KV Mechelen | - | K Beerschot VA | 3:2 | ||||
| 27. Jornada | 12.02.2022 | KV Mechelen | - | KV Oostende | 3:0 | ||||
| 24. Jornada | 16.02.2022 | KRC Genk | - | KV Mechelen | 4:1 | ||||
| 28. Jornada | 20.02.2022 | Royal Antwerp FC | - | KV Mechelen | 1:2 | ||||
| 29. Jornada | 26.02.2022 | KV Mechelen | - | Cercle Brugge | 2:2 | ||||
| 30. Jornada | 04.03.2022 | Sint-Truidense VV | - | KV Mechelen | 1:1 | ||||
| 31. Jornada | 12.03.2022 | KV Mechelen | - | Sporting Charleroi | 2:2 | ||||
| 32. Jornada | 19.03.2022 | KAS Eupen | - | KV Mechelen | 1:1 | ||||
| 33. Jornada | 02.04.2022 | KV Mechelen | - | KV Kortrijk | 3:2 |
Bélgica