| 7. Jornada | 19.09.2021 | FK Bregalnica Štip | - | GFK Tikvesh | 2:0 | ||||
| 8. Jornada | 26.09.2021 | GFK Tikvesh | - | Makedonija GP | 3:0 | ||||
| 9. Jornada | 02.10.2021 | FK Pelister | - | GFK Tikvesh | 0:0 | ||||
| 11. Jornada | 24.10.2021 | FK Skopje | - | GFK Tikvesh | 2:1 | ||||
| 12. Jornada | 30.10.2021 | KF Shkëndija 79 | - | GFK Tikvesh | 1:1 | ||||
| 13. Jornada | 06.11.2021 | GFK Tikvesh | - | FK Borec | 2:1 | ||||
| 14. Jornada | 21.11.2021 | FK AP Brera Strumica | - | GFK Tikvesh | 3:2 | ||||
| 15. Jornada | 28.11.2021 | GFK Tikvesh | - | FK Rabotnički | 2:0 | ||||
| 16. Jornada | 05.12.2021 | FC Struga | - | GFK Tikvesh | 0:0 |  |
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| 17. Jornada | 08.12.2021 | FK Renova | - | GFK Tikvesh | 1:1 | ||||
| 18. Jornada | 11.12.2021 | GFK Tikvesh | - | FK Bregalnica Štip | 1:3 |
Macedonia del Norte