| 1. Jornada | 25.07.2021 | Spartak Trnava | - | FK Pohronie | 2:0 | ||||
| 2. Jornada | 31.07.2021 | FK Pohronie | - | MFK Zemplín Michalovce | 2:0 | ||||
| 3. Jornada | 08.08.2021 | MŠK Žilina | - | FK Pohronie | 3:1 | ||||
| 4. Jornada | 14.08.2021 | FK Pohronie | - | ŠKF Sereď | 1:1 | ||||
| 5. Jornada | 20.08.2021 | Zlaté Moravce | - | FK Pohronie | 1:0 | ||||
| 6. Jornada | 27.08.2021 | FK Pohronie | - | FC DAC 1904 | 0:3 |  |
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| 8. Jornada | 18.09.2021 | Tatran Liptovský Mikuláš | - | FK Pohronie | 5:1 | ||||
| 9. Jornada | 24.09.2021 | FK Pohronie | - | AS Trenčín | 2:2 | ||||
| 13. Jornada | 30.10.2021 | MFK Zemplín Michalovce | - | FK Pohronie | 0:2 | ||||
| 17. Jornada | 04.12.2021 | FC DAC 1904 | - | FK Pohronie | 2:0 |
Polonia