| 1. Jornada | 24.01.2016 | Club Nacional | - | Guaraní | 2:1 | ||||
| 2. Jornada | 30.01.2016 | Guaraní | - | Deportivo Capiatá | 0:3 | ||||
| 5. Jornada | 15.02.2016 | Sportivo Luqueño | - | Guaraní | 1:2 |  |
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| 6. Jornada | 21.02.2016 | Guaraní | - | General Caballero ZC | 1:2 | ||||
| 7. Jornada | 27.02.2016 | River Plate | - | Guaraní | 1:1 | ||||
| 8. Jornada | 01.03.2016 | Club Rubio Ñu | - | Guaraní | 2:2 | ||||
| 9. Jornada | 05.03.2016 | Guaraní | - | Club Olimpia | 0:2 | ||||
| 11. Jornada | 20.03.2016 | Guaraní | - | Libertad | 1:3 | ||||
| 3. Jornada | 26.03.2016 | General Díaz | - | Guaraní | 3:2 | ||||
| 12. Jornada | 03.04.2016 | Guaraní | - | Club Nacional | 1:0 | ||||
| 14. Jornada | 11.04.2016 | Guaraní | - | General Díaz | 3:0 | ||||
| 16. Jornada | 22.04.2016 | Guaraní | - | Sportivo Luqueño | 3:2 | ||||
| 18. Jornada | 01.05.2016 | Guaraní | - | River Plate | 4:2 |
Paraguay