| 2. Jornada | 14.08.2021 | Oxford United | - | Charlton Athletic | 2:1 |  |
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| 3. Jornada | 17.08.2021 | Oxford United | - | Crewe Alexandra | 1:0 | |
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| 4. Jornada | 21.08.2021 | Bolton Wanderers | - | Oxford United | 2:1 | ||||
| 5. Jornada | 28.08.2021 | Oxford United | - | Lincoln City | 3:1 | ||||
| 6. Jornada | 04.09.2021 | AFC Wimbledon | - | Oxford United | 3:1 | ||||
| 7. Jornada | 11.09.2021 | Oxford United | - | Wycombe Wanderers | 0:0 | |
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| 8. Jornada | 18.09.2021 | Cheltenham Town | - | Oxford United | 1:0 | ||||
| 9. Jornada | 25.09.2021 | Oxford United | - | Gillingham FC | 1:1 | ||||
| 10. Jornada | 28.09.2021 | Oxford United | - | Accrington Stanley | 5:1 | ||||
| 11. Jornada | 02.10.2021 | Sheffield Wednesday | - | Oxford United | 1:2 | |
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| 14. Jornada | 19.10.2021 | Oxford United | - | Shrewsbury Town | 2:0 | ||||
| 15. Jornada | 23.10.2021 | Burton Albion | - | Oxford United | 1:3 | ||||
| 16. Jornada | 30.10.2021 | Oxford United | - | Morecambe FC | 3:1 |
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