| 8. Jornada | 15.12.2021 | PAE Chania | - | PS Kalamata | 1:2 | ||||
| 9. Jornada | 18.12.2021 | Panathinaikos II | - | PAE Chania | 0:2 |  |
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| 10. Jornada | 29.12.2021 | PAE Chania | - | AE Karaiskakis | 4:0 | ||||
| 13. Jornada | 12.01.2022 | Diagoras FC | - | PAE Chania | 2:2 | |
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| 15. Jornada | 23.01.2022 | PAE Chania | - | APS Zakynthos | 5:1 | ||||
| 16. Jornada | 30.01.2022 | OFI Ierapetra | - | PAE Chania | 0:0 | ||||
| 11. Jornada | 02.02.2022 | Ergotelis | - | PAE Chania | 0:0 | ||||
| 17. Jornada | 06.02.2022 | PAE Chania | - | GS Kallithea | 0:0 | ||||
| 12. Jornada | 09.02.2022 | PAE Chania | - | Asteras Vlachioti | 3:1 | ||||
| 18. Jornada | 13.02.2022 | PAE Chania | - | AO Egaleo | 1:0 | ||||
| 19. Jornada | 16.02.2022 | Irodotos | - | PAE Chania | 2:2 | |
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| 20. Jornada | 20.02.2022 | PAE Chania | - | Levadiakos | 3:1 | |
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| 21. Jornada | 27.02.2022 | AS Rhodos | - | PAE Chania | 0:1 | ||||
| 33. Jornada | 27.04.2022 | PAE Chania | - | OFI Ierapetra | 2:0 | ||||
| 34. Jornada | 01.05.2022 | GS Kallithea | - | PAE Chania | 3:1 |
Grecia