| 1. Jornada | 20.01.2022 | Victoria | - | Real España | 4:1 | ||||
| 2. Jornada | 23.01.2022 | Victoria | - | Real Sociedad | 2:0 | ||||
| 3. Jornada | 06.02.2022 | Platense | - | Victoria | 0:2 |  |
|||
| 4. Jornada | 08.02.2022 | Motagua | - | Victoria | 1:0 | ||||
| 6. Jornada | 19.02.2022 | Marathón | - | Victoria | 2:3 | |
|||
| 7. Jornada | 27.02.2022 | Victoria | - | Vida | 1:2 | ||||
| 8. Jornada | 04.03.2022 | Honduras Progreso | - | Victoria | 2:1 | ||||
| 11. Jornada | 20.03.2022 | Real Sociedad | - | Victoria | 1:3 | |
 |
||
| 12. Jornada | 03.04.2022 | Victoria | - | Motagua | 1:0 | |
|||
| 13. Jornada | 07.04.2022 | Lobos UPNFM | - | Victoria | 0:3 | ||||
| 14. Jornada | 10.04.2022 | Victoria | - | Marathón | 0:1 | ||||
| 15. Jornada | 14.04.2022 | Victoria | - | Honduras Progreso | 2:2 | ||||
| 16. Jornada | 21.04.2022 | Real España | - | Victoria | 3:1 | |
|||
| 17. Jornada | 24.04.2022 | Vida | - | Victoria | 1:1 | ||||
| 18. Jornada | 01.05.2022 | Victoria | - | Olimpia | 3:2 | |
Honduras