| 1. Jornada | 09.08.2021 | FC Utrecht (J) | - | MVV | 0:1 | ||||
| 2. Jornada | 13.08.2021 | MVV | - | De Graafschap | 1:3 |  |
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| 4. Jornada | 27.08.2021 | FC Volendam | - | MVV | 5:0 | ||||
| 5. Jornada | 05.09.2021 | MVV | - | Telstar | 3:0 | ||||
| 6. Jornada | 10.09.2021 | FC Emmen | - | MVV | 7:1 |  |
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| 7. Jornada | 17.09.2021 | MVV | - | FC Eindhoven | 1:0 | |
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| 8. Jornada | 27.09.2021 | Jong Ajax | - | MVV | 3:1 | ||||
| 9. Jornada | 01.10.2021 | MVV | - | ADO Den Haag | 2:6 | |
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| 10. Jornada | 09.10.2021 | VVV-Venlo | - | MVV | 2:0 | ||||
| 11. Jornada | 15.10.2021 | MVV | - | FC Dordrecht | 2:1 | ||||
| 12. Jornada | 22.10.2021 | NAC Breda | - | MVV | 3:0 | ||||
| 15. Jornada | 15.11.2021 | MVV | - | FC Den Bosch | 0:1 | ||||
| 17. Jornada | 26.11.2021 | MVV | - | Jong PSV | 1:2 | ||||
| 13. Jornada | 29.11.2021 | MVV | - | Roda JC Kerkrade | 1:1 | ||||
| 18. Jornada | 03.12.2021 | MVV | - | TOP Oss | 1:1 | ||||
| 19. Jornada | 10.12.2021 | SBV Excelsior | - | MVV | 2:1 | ||||
| 21. Jornada | 07.01.2022 | Roda JC Kerkrade | - | MVV | 1:0 | ||||
| 22. Jornada | 14.01.2022 | Telstar | - | MVV | 2:1 | |
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| 23. Jornada | 21.01.2022 | MVV | - | FC Volendam | 0:1 |
Bélgica