| 1. Jornada | 28.09.2020 | Real España | - | Olimpia | 1:1 |  |
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| 2. Jornada | 07.10.2020 | Platense | - | Real España | 1:0 | ||||
| 3. Jornada | 12.10.2020 | Real España | - | Honduras Progreso | 5:0 | ||||
| 4. Jornada | 14.10.2020 | Marathón | - | Real España | 3:0 |  |
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| 8. Jornada | 29.10.2020 | Honduras Progreso | - | Real España | 0:3 | |
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| 9. Jornada | 02.11.2020 | Real España | - | Marathón | 0:1 | ||||
| 13. Jornada | 15.11.2020 | Lobos UPNFM | - | Real España | 1:1 | |
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| 10. Jornada | 22.11.2020 | Vida | - | Real España | 2:2 |  |
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| 12. Jornada | 30.11.2020 | Real España | - | Motagua | 0:1 | |
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| 6. Jornada | 07.12.2020 | Olimpia | - | Real España | 1:0 | ||||
| 14. Jornada | 12.12.2020 | Real Sociedad | - | Real España | 1:2 |
Honduras