| 2. Jornada | 15.08.2021 | KF Shkëndija 79 | - | FK Renova | 1:2 | ||||
| 3. Jornada | 18.08.2021 | FK Renova | - | FK Borec | 2:0 | ||||
| 4. Jornada | 22.08.2021 | FK AP Brera Strumica | - | FK Renova | 2:1 | ||||
| 8. Jornada | 26.09.2021 | FK Renova | - | FK Bregalnica Štip | 5:2 | ||||
| 10. Jornada | 16.10.2021 | FK Renova | - | FK Pelister | 2:0 | ||||
| 12. Jornada | 30.10.2021 | FK Skopje | - | FK Renova | 0:0 | ||||
| 17. Jornada | 08.12.2021 | FK Renova | - | GFK Tikvesh | 1:1 | ||||
| 18. Jornada | 14.12.2021 | FC Struga | - | FK Renova | 1:0 | ||||
| 27. Jornada | 10.04.2022 | KF Shkëndija 79 | - | FK Renova | 1:1 | ||||
| 29. Jornada | 23.04.2022 | KF Shkupi | - | FK Renova | 2:0 | ||||
| 31. Jornada | 04.05.2022 | GFK Tikvesh | - | FK Renova | 0:1 | ||||
| 33. Jornada | 15.05.2022 | FK Borec | - | FK Renova | 1:5 |  |
Macedonia del Norte