| 16. Jornada | 28.11.2021 | Spartak Trnava | - | MFK Ružomberok | 0:3 | ||||
| 17. Jornada | 05.12.2021 | MŠK Žilina | - | Spartak Trnava | 0:1 | ||||
| 18. Jornada | 10.12.2021 | Spartak Trnava | - | MFK Zemplín Michalovce | 2:0 | ||||
| 19. Jornada | 18.12.2021 | ŠKF Sereď | - | Spartak Trnava | 0:1 | ||||
| 20. Jornada | 13.02.2022 | Spartak Trnava | - | FC DAC 1904 | 1:1 | ||||
| 21. Jornada | 19.02.2022 | Spartak Trnava | - | AS Trenčín | 0:0 |
Siria