| 1. Jornada | 01.08.2021 | Real Estelí FC | - | H&H Export Sébaco | 4:0 | ||||
| 2. Jornada | 10.08.2021 | UNAN Managua | - | H&H Export Sébaco | 0:2 | ||||
| 3. Jornada | 15.08.2021 | H&H Export Sébaco | - | Club Deportivo Ocotal | 0:1 | ||||
| 4. Jornada | 22.08.2021 | H&H Export Sébaco | - | Managua FC | 0:0 | ||||
| 5. Jornada | 29.08.2021 | Juventus Managua | - | H&H Export Sébaco | 1:0 |  |
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| 6. Jornada | 03.09.2021 | ART Municipal Jalapa | - | H&H Export Sébaco | 0:2 | ||||
| 7. Jornada | 12.09.2021 | H&H Export Sébaco | - | CD Walter Ferretti | 4:8 | ||||
| 8. Jornada | 19.09.2021 | Diriangén FC | - | H&H Export Sébaco | 1:0 | ||||
| 10. Jornada | 02.10.2021 | H&H Export Sébaco | - | Real Estelí FC | 1:3 |
Honduras