| 1. Jornada | 10.01.2021 | Atlas Guadalajara | - | CF Monterrey | 0:2 |  |
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| 2. Jornada | 18.01.2021 | Gallos Blancos | - | Atlas Guadalajara | 1:0 | ||||
| 3. Jornada | 24.01.2021 | Atlas Guadalajara | - | UANL Tigres | 0:2 | ||||
| 4. Jornada | 31.01.2021 | Pumas UNAM | - | Atlas Guadalajara | 0:0 | ||||
| 5. Jornada | 07.02.2021 | Atlas Guadalajara | - | Santos Laguna | 1:1 | |
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| 8. Jornada | 28.02.2021 | Deportivo Toluca | - | Atlas Guadalajara | 0:0 | ||||
| 9. Jornada | 03.03.2021 | Atlas Guadalajara | - | Atlético San Luis | 3:1 | |
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| 10. Jornada | 07.03.2021 | Atlas Guadalajara | - | FC Juárez | 2:0 | ||||
| 11. Jornada | 13.03.2021 | Puebla FC | - | Atlas Guadalajara | 0:1 | ||||
| 12. Jornada | 21.03.2021 | Cruz Azul | - | Atlas Guadalajara | 3:2 |  |
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| 13. Jornada | 04.04.2021 | Atlas Guadalajara | - | Club Tijuana | 1:0 | |
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| 14. Jornada | 11.04.2021 | Atlas Guadalajara | - | Club León | 1:3 | ||||
| 15. Jornada | 17.04.2021 | Mazatlán FC | - | Atlas Guadalajara | 0:0 | ||||
| 16. Jornada | 25.04.2021 | Atlas Guadalajara | - | Deportivo Guadalajara | 0:1 | ||||
| 17. Jornada | 01.05.2021 | Club Necaxa | - | Atlas Guadalajara | 1:5 |
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