| 8. Jornada | 13.08.2022 | Atlético San Luis [] | - | Deportivo Guadalajara [] | 2:1 |  |
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| 9. Jornada | 20.08.2022 | Deportivo Guadalajara [] | - | Mazatlán FC [] | 4:1 | ||||
| 10. Jornada | 28.08.2022 | Deportivo Guadalajara [] | - | Santos Laguna [] | 1:1 | ||||
| 11. Jornada | 03.09.2022 | Mazatlán FC [] | - | Deportivo Guadalajara [] | 2:8 | ||||
| 14. Jornada | 25.09.2022 | Deportivo Guadalajara [] | - | Club Tijuana [] | 2:1 | ||||
| 16. Jornada | 08.10.2022 | Club León [] | - | Deportivo Guadalajara [] | 1:1 | ||||
| 17. Jornada | 15.10.2022 | Deportivo Guadalajara [] | - | UANL Tigres [] | 6:1 | ||||
| 18. Jornada | 22.10.2022 | Atlas Guadalajara [] | - | Deportivo Guadalajara [] | 1:0 |
México