| 1. Jornada | 05.03.2022 | APOEL Nikosia | - | Aris Limassol | 1:1 |  |
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| 2. Jornada | 13.03.2022 | AEK Larnaca | - | APOEL Nikosia | 1:2 |  |
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| 3. Jornada | 20.03.2022 | APOEL Nikosia | - | Apollon Limassol | 0:0 | ||||
| 4. Jornada | 02.04.2022 | Anorthosis Famagusta | - | APOEL Nikosia | 4:1 | ||||
| 5. Jornada | 10.04.2022 | APOEL Nikosia | - | Paphos FC | 2:1 | |
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| 6. Jornada | 17.04.2022 | Aris Limassol | - | APOEL Nikosia | 1:2 | ||||
| 8. Jornada | 08.05.2022 | Apollon Limassol | - | APOEL Nikosia | 3:2 | ||||
| 9. Jornada | 15.05.2022 | APOEL Nikosia | - | Anorthosis Famagusta | 1:1 | ||||
| 10. Jornada | 22.05.2022 | Paphos FC | - | APOEL Nikosia | 3:1 |
Chipre