| 2. Jornada | 31.07.2021 | Real Santander | - | Unión Magdalena | 3:3 | ||||
| 3. Jornada | 08.08.2021 | Boca Juniors de Cali | - | Real Santander | 0:0 | ||||
| 4. Jornada | 14.08.2021 | Real Santander | - | Real Cartagena | 2:2 | ||||
| 5. Jornada | 20.08.2021 | Leones FC | - | Real Santander | 2:1 | ||||
| 6. Jornada | 28.08.2021 | Real Santander | - | Llaneros FC | 3:1 | ||||
| 1. Jornada | 01.09.2021 | Cortuluá | - | Real Santander | 2:0 | ||||
| 7. Jornada | 06.09.2021 | Tigres FC | - | Real Santander | 2:0 | ||||
| 8. Jornada | 11.09.2021 | Real Santander | - | Barranquilla FC | 1:1 | ||||
| 9. Jornada | 18.09.2021 | Bogotá FC | - | Real Santander | 1:1 | ||||
| 10. Jornada | 24.09.2021 | Real Santander | - | Atlético FC | 0:2 | ||||
| 14. Jornada | 24.10.2021 | Real Santander | - | Fortaleza FC | 1:1 |  |
Colombia