| 11. Jornada | 15.07.2021 | Rangers | - | Santa Cruz | 1:3 | ||||
| 14. Jornada | 08.08.2021 | Cobreloa | - | Santa Cruz | 0:1 | ||||
| 15. Jornada | 15.08.2021 | Santa Cruz | - | San Marcos | 2:0 | ||||
| 19. Jornada | 05.09.2021 | Puerto Montt | - | Santa Cruz | 2:2 | ||||
| 23. Jornada | 03.10.2021 | Deportes Iquique | - | Santa Cruz | 6:1 |  |
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| 25. Jornada | 12.10.2021 | San Luis | - | Santa Cruz | 0:0 | ||||
| 26. Jornada | 19.10.2021 | Santa Cruz | - | Rangers | 1:0 | ||||
| 27. Jornada | 23.10.2021 | CD Magallanes | - | Santa Cruz | 1:1 |
Chile