| 1. Jornada | 16.07.2021 | Sepsi OSK | - | Academica Clinceni | 2:0 | ||||
| 3. Jornada | 02.08.2021 | Sepsi OSK | - | CS Mioveni | 1:2 | ||||
| 4. Jornada | 09.08.2021 | Farul Constanța | - | Sepsi OSK | 1:0 | ||||
| 5. Jornada | 15.08.2021 | Sepsi OSK | - | Argeș Pitești | 0:2 | ||||
| 6. Jornada | 23.08.2021 | FCSB | - | Sepsi OSK | 1:1 | ||||
| 7. Jornada | 29.08.2021 | Sepsi OSK | - | FC Botoşani | 1:1 |  |
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| 8. Jornada | 13.09.2021 | CS Universitatea Craiova | - | Sepsi OSK | 1:1 |  |
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| 14. Jornada | 31.10.2021 | Sepsi OSK | - | Dinamo Bucureşti | 4:1 | ||||
| 15. Jornada | 06.11.2021 | FC Universitatea Craiova | - | Sepsi OSK | 1:1 | ||||
| 18. Jornada | 05.12.2021 | CS Mioveni | - | Sepsi OSK | 0:2 | ||||
| 19. Jornada | 12.12.2021 | Sepsi OSK | - | Farul Constanța | 1:0 | ||||
| 20. Jornada | 15.12.2021 | Argeș Pitești | - | Sepsi OSK | 1:1 | |
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| 21. Jornada | 19.12.2021 | Sepsi OSK | - | FCSB | 0:0 | ||||
| 25. Jornada | 08.02.2022 | Sepsi OSK | - | Gaz Metan Mediaş | 2:0 | ||||
| 26. Jornada | 11.02.2022 | Rapid Bucureşti | - | Sepsi OSK | 1:1 | ||||
| 27. Jornada | 19.02.2022 | FC Voluntari | - | Sepsi OSK | 3:1 | |
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| 28. Jornada | 26.02.2022 | Sepsi OSK | - | CFR Cluj | 0:2 | ||||
| 29. Jornada | 01.03.2022 | Dinamo Bucureşti | - | Sepsi OSK | 1:3 | |
Rumania