| 4. Jornada | 07.02.2022 | Club León [Sub 20] | - | Cruz Azul [Sub 20] | 2:1 | ||||
| 6. Jornada | 19.02.2022 | Club León [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 3:0 | ||||
| 7. Jornada | 25.02.2022 | Club Necaxa [Sub 20] | - | Club León [Sub 20] | 0:3 | ||||
| 9. Jornada | 04.03.2022 | FC Juárez [Sub 20] | - | Club León [Sub 20] | 0:1 |  |
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| 12. Jornada | 03.04.2022 | Club León [Sub 20] | - | Gallos Blancos [Sub 20] | 2:1 | ||||
| 14. Jornada | 16.04.2022 | Club León [Sub 20] | - | Puebla FC [Sub 20] | 4:1 | ||||
| 15. Jornada | 20.04.2022 | CF América [Sub 20] | - | Club León [Sub 20] | 2:1 |  |
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| 17. Jornada | 01.05.2022 | Club León [Sub 20] | - | Deportivo Toluca [Sub 20] | 3:1 |
México