| 1. Jornada | 06.01.2019 | Club León | - | UANL Tigres | 2:2 |  |
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| 2. Jornada | 13.01.2019 | CF Monterrey | - | Club León | 2:2 |  |
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| 3. Jornada | 21.01.2019 | Club León | - | Club Tijuana | 0:1 | ||||
| 4. Jornada | 27.01.2019 | Gallos Blancos | - | Club León | 0:4 | ||||
| 5. Jornada | 03.02.2019 | Club León | - | Cruz Azul | 2:0 | ||||
| 6. Jornada | 10.02.2019 | CF América | - | Club León | 0:3 | ||||
| 7. Jornada | 17.02.2019 | Club León | - | Deportivo Toluca | 3:0 | ||||
| 8. Jornada | 24.02.2019 | Pumas UNAM | - | Club León | 1:3 | ||||
| 9. Jornada | 03.03.2019 | Club León | - | Santos Laguna | 3:0 | ||||
| 10. Jornada | 10.03.2019 | Lobos BUAP | - | Club León | 0:1 | ||||
| 11. Jornada | 18.03.2019 | Club León | - | CD Veracruz | 2:0 | ||||
| 12. Jornada | 30.03.2019 | Monarcas Morelia | - | Club León | 2:3 | ||||
| 13. Jornada | 07.04.2019 | Club León | - | Club Necaxa | 2:1 | ||||
| 14. Jornada | 13.04.2019 | Puebla FC | - | Club León | 0:3 | ||||
| 16. Jornada | 28.04.2019 | Deportivo Guadalajara | - | Club León | 2:1 | ||||
| 17. Jornada | 05.05.2019 | Club León | - | CF Pachuca | 2:1 |
Colombia