| 7. Jornada | 21.02.2021 | Real Santander | - | Unión Magdalena | 0:1 | ||||
| 2. Jornada | 24.02.2021 | Cortuluá | - | Real Santander | 1:0 | ||||
| 8. Jornada | 01.03.2021 | Real Santander | - | Deportes Quindío | 1:1 | ||||
| 9. Jornada | 04.03.2021 | Real Santander | - | Orsomarso SC | 1:2 | ||||
| 10. Jornada | 07.03.2021 | Real Santander | - | Boca Juniors de Cali | 0:1 |  |
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| 12. Jornada | 21.03.2021 | Tigres FC | - | Real Santander | 1:1 | ||||
| 13. Jornada | 27.03.2021 | Bogotá FC | - | Real Santander | 1:4 |
Colombia