| 2. Jornada | 16.01.2022 | Deportivo Saprissa | - | AD San Carlos | 1:2 |  |
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| 3. Jornada | 22.01.2022 | AD San Carlos | - | Municipal Pérez Zeledón | 1:1 | ||||
| 6. Jornada | 15.02.2022 | AD San Carlos | - | AD Guanacasteca | 3:1 | |
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| 7. Jornada | 19.02.2022 | Municipal Grecia | - | AD San Carlos | 0:1 | ||||
| 8. Jornada | 26.02.2022 | AD San Carlos | - | Jicaral | 1:1 | ||||
| 9. Jornada | 02.03.2022 | CS Cartaginés | - | AD San Carlos | 1:1 |  |
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| 10. Jornada | 07.03.2022 | AD San Carlos | - | LD Alajuelense | 0:3 | ||||
| 1. Jornada | 13.03.2022 | AD San Carlos | - | Santos de Guápiles | 1:0 | ||||
| 11. Jornada | 01.04.2022 | Sporting FC | - | AD San Carlos | 4:0 | ||||
| 12. Jornada | 06.04.2022 | Santos de Guápiles | - | AD San Carlos | 1:1 | ||||
| 13. Jornada | 10.04.2022 | AD San Carlos | - | Deportivo Saprissa | 4:1 | ||||
| 20. Jornada | 09.05.2022 | AD San Carlos | - | CS Cartaginés | 3:2 | |
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| 21. Jornada | 13.05.2022 | LD Alajuelense | - | AD San Carlos | 1:0 | ||||
| 22. Jornada | 15.05.2022 | AD San Carlos | - | Sporting FC | 2:1 | |
Costa Rica
Nicaragua