6. Jornada | 24.08.2021 | Guaraní | - | Libertad | 2:2 | ||||
7. Jornada | 30.08.2021 | River Plate | - | Guaraní | 1:5 | ||||
9. Jornada | 19.09.2021 | Cerro Porteño | - | Guaraní | 0:0 | ||||
11. Jornada | 03.10.2021 | Guaraní | - | Club Nacional | 1:1 | ||||
12. Jornada | 18.10.2021 | 12 de Octubre de Itauguá | - | Guaraní | 1:2 | ||||
14. Jornada | 31.10.2021 | Guaraní | - | Sportivo Luqueño | 2:1 | ||||
16. Jornada | 20.11.2021 | Guaraní | - | River Plate | 2:1 | ||||
17. Jornada | 28.11.2021 | Guaireña FC | - | Guaraní | 1:1 | ||||
18. Jornada | 05.12.2021 | Guaraní | - | Cerro Porteño | 2:2 |