| 2. Jornada | 14.01.2022 | Gallos Blancos [Sub 20] | - | Pumas UNAM [Sub 20] | 0:1 | ||||
| 3. Jornada | 23.01.2022 | Pumas UNAM [Sub 20] | - | UANL Tigres [Sub 20] | 2:1 | ||||
| 5. Jornada | 13.02.2022 | Pumas UNAM [Sub 20] | - | Club León [Sub 20] | 2:1 | ||||
| 7. Jornada | 26.02.2022 | Pumas UNAM [Sub 20] | - | CF América [Sub 20] | 0:1 | ||||
| 11. Jornada | 19.03.2022 | Pumas UNAM [Sub 20] | - | Club Necaxa [Sub 20] | 1:2 |  |
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| 9. Jornada | 27.03.2022 | Pumas UNAM [Sub 20] | - | Mazatlán FC [Sub 20] | 3:0 |  |
México