| 2. Jornada | 25.07.2021 | Cusco FC | - | Deportivo Binacional | 2:2 |  |
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| 3. Jornada | 01.08.2021 | Cusco FC | - | Alianza Universidad | 2:3 | ||||
| 4. Jornada | 04.08.2021 | FBC Melgar | - | Cusco FC | 2:2 | ||||
| 5. Jornada | 08.08.2021 | Cusco FC | - | Alianza Atlético | 3:0 | |
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| 6. Jornada | 13.08.2021 | Universidad Técnica | - | Cusco FC | 2:1 | ||||
| 7. Jornada | 17.08.2021 | Cusco FC | - | Mannucci | 2:3 | ||||
| 8. Jornada | 23.08.2021 | Sporting Cristal | - | Cusco FC | 4:1 | |
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| 10. Jornada | 11.09.2021 | Ayacucho FC | - | Cusco FC | 1:3 | ||||
| 11. Jornada | 17.09.2021 | Cusco FC | - | Alianza Lima | 0:2 | |
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| 12. Jornada | 22.09.2021 | Sport Boys | - | Cusco FC | 3:2 | ||||
| 13. Jornada | 27.09.2021 | Cusco FC | - | Academia Cantolao | 3:2 |  |
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| 14. Jornada | 03.10.2021 | Universidad San Martín | - | Cusco FC | 1:1 | ||||
| 15. Jornada | 18.10.2021 | Cusco FC | - | Deportivo Municipal | 3:5 | ||||
| 16. Jornada | 23.10.2021 | Universitario de Deportes | - | Cusco FC | 2:1 | |
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| 17. Jornada | 30.10.2021 | Cusco FC | - | Sport Huancayo | 2:1 |
Colombia