| 10. Jornada | 17.10.2020 | FK Senica | - | MFK Ružomberok | 1:2 | ||||
| 11. Jornada | 24.10.2020 | FK Pohronie | - | FK Senica | 1:2 | ||||
| 12. Jornada | 31.10.2020 | MŠK Žilina | - | FK Senica | 3:1 | ||||
| 13. Jornada | 17.11.2020 | FK Senica | - | ŠKF Sereď | 2:2 | ||||
| 14. Jornada | 21.11.2020 | MFK Zemplín Michalovce | - | FK Senica | 0:1 | ||||
| 15. Jornada | 29.11.2020 | FK Senica | - | Slovan Bratislava | 0:3 |  |
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| 16. Jornada | 05.12.2020 | FC Nitra | - | FK Senica | 1:1 | ||||
| 17. Jornada | 12.12.2020 | FK Senica | - | Zlaté Moravce | 1:1 | ||||
| 18. Jornada | 15.12.2020 | FC DAC 1904 | - | FK Senica | 2:0 | ||||
| 19. Jornada | 13.02.2021 | Spartak Trnava | - | FK Senica | 1:0 | ||||
| 20. Jornada | 20.02.2021 | FK Senica | - | AS Trenčín | 2:3 | ||||
| 21. Jornada | 27.02.2021 | MFK Ružomberok | - | FK Senica | 2:3 | |
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| 22. Jornada | 06.03.2021 | FK Senica | - | FK Pohronie | 1:1 |
Francia