| 4. Jornada | 10.09.2021 | NK Opatija | - | NK BSK Bijelo Brdo | 0:0 | ||||
| 5. Jornada | 15.09.2021 | Dinamo Zagreb II | - | NK Opatija | 2:1 | ||||
| 6. Jornada | 18.09.2021 | NK Opatija | - | NK Solin | 1:1 | ||||
| 7. Jornada | 26.09.2021 | NK Croatia Zmijavci | - | NK Opatija | 3:0 | ||||
| 8. Jornada | 02.10.2021 | NK Osijek II | - | NK Opatija | 0:2 |  |
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| 9. Jornada | 16.10.2021 | NK Opatija | - | NK Varaždin | 2:2 |  |
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| 10. Jornada | 23.10.2021 | NK Rudeš | - | NK Opatija | 3:0 | ||||
| 11. Jornada | 30.10.2021 | NK Opatija | - | NK Jarun | 0:1 | ||||
| 12. Jornada | 05.11.2021 | NK Sesvete | - | NK Opatija | 2:1 | ||||
| 16. Jornada | 12.02.2022 | NK Opatija | - | HNK Cibalia | 2:1 | ||||
| 22. Jornada | 02.04.2022 | NK Opatija | - | NK Croatia Zmijavci | 2:1 | ||||
| 23. Jornada | 09.04.2022 | NK Opatija | - | NK Osijek II | 1:2 | ||||
| 24. Jornada | 16.04.2022 | NK Varaždin | - | NK Opatija | 4:0 | ||||
| 25. Jornada | 23.04.2022 | NK Opatija | - | NK Rudeš | 3:1 | |
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| 26. Jornada | 30.04.2022 | NK Jarun | - | NK Opatija | 2:1 | ||||
| 27. Jornada | 06.05.2022 | NK Opatija | - | NK Sesvete | 1:1 | ||||
| 28. Jornada | 14.05.2022 | NK Dugopolje | - | NK Opatija | 3:2 | ||||
| 30. Jornada | 28.05.2022 | HNK Orijent Rijeka | - | NK Opatija | 3:0 |
Croacia